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Dominant lethal mutations in male mice fed γ-irradiated diet

✍ Scribed by P.S. Chauhan; M. Aravindakshan; A.S. Aiyar; K. Sundaram

Book ID
114025983
Publisher
Elsevier Science
Year
1975
Weight
433 KB
Volume
13
Category
Article
ISSN
0015-6264

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Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal