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Male-mediated dominant lethal mutations in mice following prooxidant treatment

✍ Scribed by Thimappa Rajesh Kumar; Muralidhara

Book ID
117767837
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
69 KB
Volume
444
Category
Article
ISSN
1383-5718

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Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal