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Dominant lethal mutations induced in male mice by methyl methanesulphonate

โœ Scribed by Partington, M; Bateman, A J


Book ID
109856447
Publisher
Nature Publishing Group
Year
1964
Tongue
English
Weight
126 KB
Volume
19
Category
Article
ISSN
0018-067X

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๐Ÿ“œ SIMILAR VOLUMES


Dominant lethal mutations in male mice
โœ U. H. Ehling ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 648 KB

Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p

Induction of dominant lethal mutations i
โœ U. H. Ehling ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 342 KB

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal