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Does activated protein C-resistant factor V contribute to thrombin generation in hemophilic plasma?

โœ Scribed by M. H. A. BOS; D. W. E. MEIJERMAN; C. VAN DER ZWAAN; K. MERTENS

Book ID
109148840
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
325 KB
Volume
3
Category
Article
ISSN
1538-7933

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Detection of a common mutation in factor V gene responsible for resistance to activated protein C causing predisposition to thrombosis
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Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured

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Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers
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## Background: Activated protein c (apc) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis. ## Objectives: To determine the prevalence of apc resistance due to factor v leiden mutation in patients with leg ulcers. ## Methods: Within a 2-year-p