Changes of Resistance to Activated Protein C in The Course of Pregnancy and Prevalence of Factor V Mutation
โ Scribed by Shigeko Mimuro; Robert Lahoud; Lucinda Beutler; Brian Trudinger
- Book ID
- 109056707
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1998
- Tongue
- English
- Weight
- 438 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0004-8666
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๐ SIMILAR VOLUMES
## Objective: To test a possible association between activated protein C resistance and intrauterine fetal death. Methods: The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy cont
To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the fa
## Background: Activated protein c (apc) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis. ## Objectives: To determine the prevalence of apc resistance due to factor v leiden mutation in patients with leg ulcers. ## Methods: Within a 2-year-p
Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured