Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers

✍ Scribed by Y. Gaber; H-J. Siemens; W. Schmeller

• Book ID: 104459747
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 201 KB
• Volume: 144
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2001.04081.x

✦ Synopsis

Background:

Activated protein c (apc) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis.

Objectives:

To determine the prevalence of apc resistance due to factor v leiden mutation in patients with leg ulcers.

Methods:

Within a 2-year-period 100 consecutive patients with leg ulcers were examined for factor v leiden mutation.

Results:

Apc resistance due to factor v leiden mutation was detected in 19 of 53 patients (36%) with post-thrombotic leg ulcers and in three of 47 patients (6%) with ulcers caused by primary varicosis. in a healthy control group apc resistance due to factor v leiden mutation was found in five of 96 (5%) volunteers.

Conclusions:

In view of this high prevalence of apc resistance of 36%, which has never previously been reported, patients with post-thrombotic leg ulcers should be investigated for apc resistance.