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High prevalence of activated protein C resistance due to factor V leiden mutation in cases of intrauterine fetal death

✍ Scribed by H. Rothbart; G. Ohel; J. Younis; N. Lanir; B. Brenner

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 27 KB
Volume: 8
Category: Article
ISSN: 1057-0802
DOI: 10.1002/(sici)1520-6661(199909/10)8:5<228::aid-mfm6>3.0.co;2-2

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✦ Synopsis

Objective:

To test a possible association between activated protein C resistance and intrauterine fetal death. Methods: The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls. Results: Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P ϭ 0.013).

Conclusion:

Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.

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Detection of a common mutation in factor

Detection of a common mutation in factor V gene responsible for resistance to activated protein C causing predisposition to thrombosis

✍ A. Ferreira-Gonzalez; LM Fisher; CM Lehman; MH Langley; DH Lofland; Q Xia; NX Ng 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB

Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured