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Activated protein C resistance and the factor V Leiden mutation in children with thrombosis

โœ Scribed by Sifontes, Maria T.; Nuss, Rachelle; Hunger, Stephen P.; Waters, Jill; Jacobson, Linda J.; Manco-Johnson, Marilyn

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
22 KB
Volume
57
Category
Article
ISSN
0361-8609

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โœฆ Synopsis

To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the factor V Leiden mutation. Five of 34 children (15%) had activated protein C resistance; each was heterozygous for the factor V Leiden mutation. All 5 children heterozygous for the factor V Leiden mutation suffered non-CNS venous thromboses comprising 21% of the group of children (5/24) with non-CNS venous thrombotic events. Each of these 5 children had a family history of thrombosis. In conclusion, children with non-CNS venous thrombosis should be evaluated for the factor V Leiden mutation. Children most likely affected are those with a family history of thrombosis.

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