To determine the prevalence of activated protein C resistance and the factor V Leiden mutation (position 1691, arginine 506 to glutamine substitution) in children with thrombosis, plasma samples from children with thrombosis were tested for activated protein C resistance. DNA was analyzed for the fa
Mutation in blood coagulation factor V associated with resistance to activated protein C
โ Scribed by van der Velden, Pieter A.; Reitsma, Pieter H.; Bertina, Rogier M.; Koeleman, Bobby P. C.; Koster, Ted; Rosendaal, Frits R.; Dirven, Richard J.; de Ronde, Hans
- Book ID
- 109788474
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 513 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/369064a0
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## BACKGROUND. Thromboembolic events are well recognized complications of can-
## Background: Activated protein c (apc) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis. ## Objectives: To determine the prevalence of apc resistance due to factor v leiden mutation in patients with leg ulcers. ## Methods: Within a 2-year-p
The aim of our study was to determine the prevalence of the factor V mutation (position 1691 G->A) in patients with angiographically diagnosed coronary artery disease and myocardial infarction and, as a control, in blood donors. This mutation has already been proved to be the main genetic risk facto