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Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides

โœ Scribed by Vennerstrom, Jonathan L.; Fu, Hong Ning; Ellis, William Y.; Ager, Arba L.; Wood, James K.; Andersen, Steven L.; Gerena, Lucia; Milhous, Wilbur K.


Book ID
120549659
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
678 KB
Volume
35
Category
Article
ISSN
0022-2623

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The structure and antimalarial activity
โœ Yuxiang Dong; Kevin J. McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 266 KB

An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-