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Synthesis and Antimalarial Activity of Sixteen Dispiro-1,2,4,5-tetraoxanes: Alkyl-Substituted 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes

✍ Scribed by Vennerstrom, Jonathan L.; Dong, Yuxiang; Andersen, Steven L.; Ager,, Arba L.; Fu, Hong-ning; Miller, Robert E.; Wesche, David L.; Kyle, Dennis E.; Gerena, Lucia; Walters, Sheri M.; Wood, James K.; Edwards, Geoffrey; Holme, Alexandra D.; McLean, W. Graham; Milhous, Wilbur K.


Book ID
121484108
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
67 KB
Volume
43
Category
Article
ISSN
0022-2623

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The structure and antimalarial activity
✍ Yuxiang Dong; Kevin J. McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L. πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 266 KB

An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-