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Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes: Correlations of Structural Studies with Antimalarial Activity

✍ Scribed by McCullough, Kevin J.; Wood, James K.; Bhattacharjee, Apurba K.; Dong, Yuxiang; Kyle, Dennis E.; Milhous, Wilbur K.; Vennerstrom, Jonathan L.


Book ID
121331014
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
61 KB
Volume
43
Category
Article
ISSN
0022-2623

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The structure and antimalarial activity
✍ Yuxiang Dong; Kevin J. McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L. πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 266 KB

An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-