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Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin

โœ Scribed by Amewu, Richard; Stachulski, Andrew V.; Ward, Stephen A.; Berry, Neil G.; Bray, Patrick G.; Davies, Jill; Labat, Gael; Vivas, Livia; O'Neill, Paul M.


Book ID
119944534
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
286 KB
Volume
4
Category
Article
ISSN
1477-0520

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The structure and antimalarial activity
โœ Yuxiang Dong; Kevin J. McCullough; Sergio Wittlin; Jacques Chollet; Jonathan L. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 266 KB

An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-