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Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

✍ Scribed by Semple, Graeme; Fioravanti, Beatriz; Pereira, Guillherme; Calderon, Imelda; Uy, Jane; Choi, Karoline; Xiong, Yifeng; Ren, Albert; Morgan, Michael; Dave, Vibha

Book ID
111644018
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
93 KB
Volume
51
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Discovery of Fused
ChemInform Abstract: Discovery of Fused Bicyclic Agonists of the Orphan G-Protein Coupled Receptor GPR119 with in vivo Activity in Rodent Models of Glucose Control.
✍ Graeme Semple; et al. et al. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 26 KB

## Abstract Based on a known lead, a new structural series of agonists of the pancreatic and GI‐expressed orphan G‐protein coupled receptor GPR119 are designed and synthesized.