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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

✍ Scribed by Graeme Semple; Juerg Lehmann; Amy Wong; Albert Ren; Marc Bruce; Young-Jun Shin; Carleton R. Sage; Michael Morgan; Wei-Chao Chen; Kristen Sebring; Zhi-Liang Chu; James N. Leonard; Hussein Al-Shamma; Andrew J. Grottick; Fuyong Du; Yin Liang; Keith Demarest; Robert M. Jones


Book ID
113496529
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
347 KB
Volume
22
Category
Article
ISSN
0960-894X

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ChemInform Abstract: Discovery of Fused
✍ Graeme Semple; et al. et al. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 26 KB

## Abstract Based on a known lead, a new structural series of agonists of the pancreatic and GI‐expressed orphan G‐protein coupled receptor GPR119 are designed and synthesized.