✦ LIBER ✦

Design and Synthesis of Diazatricyclodecane Agonists of the G-Protein-Coupled Receptor 119

✍ Scribed by Darout, Etzer; Robinson, Ralph P.; McClure, Kim F.; Corbett, Matthew; Li, Bryan; Shavnya, Andrei; Andrews, Melissa P.; Jones, Christopher S.; Li, Qifang,; Minich, Martha L.; Mascitti, Vincent; Guimarães, Cristiano R. W.; Munchhof, Michael J.; Bahnck, Kevin B.; Cai, Cuiman; Price, David A.; Liras, Spiros; Bonin, Paul D.; Cornelius, Peter; Wang, Ruduan; Bagdasarian, Victoria; Sobota, Colleen P.; Hornby, Sam; Masterson, Victoria M.; Joseph, Reena M.; Kalgutkar, Amit S.; Chen, Yue

Book ID: 118213552
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 975 KB
Volume: 56
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm301626p

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Optimisation of aqueous solubility in a

Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

✍ Scott, James S. ;Birch, Alan M. ;Brocklehurst, Katy J. ;Brown, Hayley S. ;Goldbe 📂 Article 📅 2013 🏛 The Royal Society of Chemistry 🌐 English ⚖ 416 KB

Discovery of the First Potent and Orally

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

✍ Semple, Graeme; Fioravanti, Beatriz; Pereira, Guillherme; Calderon, Imelda; Uy, 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 93 KB

G Protein-coupled Receptors: II. MECHANI

G Protein-coupled Receptors: II. MECHANISM OF AGONIST ACTIVATION

✍ Gether, U.; Kobilka, B. K. 📂 Article 📅 1998 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 764 KB

Identification of G protein-coupled rece

Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists

✍ Suzuki, Takayoshi; Igari, Sou-ichi; Hirasawa, Akira; Hata, Mie; Ishiguro, Masaji 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 194 KB

Discovery of a second generation agonist

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

✍ Graeme Semple; Juerg Lehmann; Amy Wong; Albert Ren; Marc Bruce; Young-Jun Shin; 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 347 KB

Agonist-selective signaling of G protein

Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications

✍ Hui Zheng; Horace H. Loh; Ping-Yee Law 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 118 KB 👁 1 views

## Abstract Agonist‐selective signaling or ligand‐biased signaling of G protein‐coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review