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Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as Dual Endothelin/Angiotensin II Receptor Antagonists.

✍ Scribed by John E. Tellew; et al. et al.


Book ID
101949445
Publisher
John Wiley and Sons
Year
2003
Weight
190 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of [14C]KT3-671, 2-Propyl-8-ox
✍ Naoto Ueyama; Takashi Yanagisawa; Tsuyoshi Tomiyama 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 263 KB 👁 1 views

## Abstract 2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium[^14^C]‐cyanide. [^14^C](KT3‐