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Direct-type catalytic Mannich reactions of amides with imines

✍ Scribed by Saito, Susumu; Tsubogo, Tetsu; Kobayashi, Sh?

Book ID
111691711
Publisher
Royal Society of Chemistry
Year
2007
Tongue
English
Weight
223 KB
Volume
12
Category
Article
ISSN
1359-7345

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## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)