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Direct Catalytic Asymmetric Mannich-Type Reaction of Thioamides

✍ Scribed by Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
402 KB
Volume
121
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Weich hilft hart: Die Titelreaktion zwischen Thioamiden und N‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereaktionen mit der Thioamideinheit unterstreichen die Nützlichkeit des Verfahrens.magnified image

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Direct Catalytic Asymmetric Mannich-Type
Direct Catalytic Asymmetric Mannich-Type Reaction of Thioamides
✍ Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)