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Direct Catalytic Asymmetric Mannich-Type Reaction of Thioamides

✍ Scribed by Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
403 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Taking the reins: The title transformation of thioamides and N‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.magnified image

📜 SIMILAR VOLUMES

Direct Catalytic Asymmetric Mannich-Type
Direct Catalytic Asymmetric Mannich-Type Reaction of Thioamides
✍ Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB 👁 1 views

## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti