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Development of a Naphthyridinone P38 Kinase Inhibitor

✍ Scribed by John Y. L. Chung; Raymond J. Cvetovich


Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract __In a continuous effort to develop improved p38 MAP (mitogen‐activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SB‐203580. 3,4‐ and 4,5‐disubstituted as well as 3,4,5‐trisubstit