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Imidazopyrimidines, Potent Inhibitors of p38 MAP Kinase.

✍ Scribed by Kenneth C. Rupert; James R. Henry; John H. Dodd; Scott A. Wadsworth; Druie E. Cavender; Gilbert C. Olini; Bohumila Fahmy; John J. Siekierka


Publisher
John Wiley and Sons
Year
2003
Weight
11 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract __In a continuous effort to develop improved p38 MAP (mitogen‐activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SB‐203580. 3,4‐ and 4,5‐disubstituted as well as 3,4,5‐trisubstit