๐”– Bobbio Scriptorium
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Novel, Potent and Selective Anilinoquinazoline and Anilinopyrimidine Inhibitors of p38 MAP Kinase.

โœ Scribed by John G. Cumming; Caroline L. McKenzie; Stuart G. Bowden; Douglas Campbell; David J. Masters; Jason Breed; Philip J. Jewsbury


Publisher
John Wiley and Sons
Year
2005
Weight
15 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract __In a continuous effort to develop improved p38 MAP (mitogenโ€activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SBโ€203580. 3,4โ€ and 4,5โ€disubstituted as well as 3,4,5โ€trisubstit