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ChemInform Abstract: Potent Inhibitors of the MAP Kinase p38.

✍ Scribed by James R. Henry; Kenneth C. Rupert; John H. Dodd; Ignatius J. Turchi; Scott A. Wadsworth; Druie E. Cavender; Peter H. Schafer; John J. Siekierka


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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## Abstract __In a continuous effort to develop improved p38 MAP (mitogen‐activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SB‐203580. 3,4‐ and 4,5‐disubstituted as well as 3,4,5‐trisubstit