Synthesis of a Naphthyridone p38 MAP Kinase Inhibitor.
β Scribed by John Y. L. Chung; Raymond J. Cvetovich; Mark McLaughlin; Joseph Amato; Fuh-Rong Tsay; Mark Jensen; Steve Weissman; Daniel Zewge
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 12 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract __In a continuous effort to develop improved p38 MAP (mitogenβactivated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SBβ203580. 3,4β and 4,5βdisubstituted as well as 3,4,5βtrisubstit
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