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p38 MAP Kinase Inhibitors: Metabolically Stabilized Piperidine-Substituted Quinolinones and Naphthyridinones.

โœ Scribed by Jianming Bao; et al. et al.


Publisher
John Wiley and Sons
Year
2006
Weight
14 KB
Volume
37
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


Substituted Isoxazoles as Potent Inhibit
โœ Stefanโ€…A. Laufer; Simona Margutti; Martinaโ€…D. Fritz ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 205 KB

## Abstract __In a continuous effort to develop improved p38 MAP (mitogenโ€activated protein) kinase inhibitors, we focused our attention on the suitability of the isoxazole ring as a bioisosteric replacement for the imidazole ring of SBโ€203580. 3,4โ€ and 4,5โ€disubstituted as well as 3,4,5โ€trisubstit