Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction
β Scribed by Goldmann, Siegfried; Stoltefuss, Juergen; Born, Liborius
- Book ID
- 121863739
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 446 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-2623
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The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-l-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary. Absolute configurations have been deduced via X-ray crystallography on a (R)-mandelic
## Abstract The __trans__ isomer of 2,7βdiβ__tert__βbutylnaphtho[1,8β__cd__][1,2]dithiole 1,2βdioxide, a __vic__βdisulfoxide of the highest thermal stability reported to date, has been resolved into its enantiomers by preparative chiral liquid chromatography. This represents the first resolution ac