Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline
โ Scribed by Selvig, Kirsten; Ruud-Christensen, Merete; Aasen, Arne J.
- Book ID
- 126989850
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 744 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Thermodynamically and kinetically stabilized asymmetric diaryltelluronium imides were synthesized and optically resolved into their enantiomers on an optically active column using mediumโpressure column chromatography. The relationship between the absolute configuration and the optical
## Abstract The enantiomers of 1โmethylโ3โ(10__H__โphenothiazineโ10โylmethyl)โ1โazoniabicyclo[2,2,2]octane iodide (1) were prepared by chiral chromatographic resolution of the precursor mequitazine (2). The (+)โ(S)โenantiomer 1b is 10โfold more potent than (โ)โ(R)โenantiomer 1a as a histamine antag