Chiral resolution and absolute configura
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Ornella Azzolina; Vittorio Dal Piaz; Simona Collina; Maria Paola Giovannoni; Car
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Article
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1997
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John Wiley and Sons
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English
β 96 KB
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In a series of 5-acyl-6-phenyl-2,4-substituted-3(2H)-pyridaziones the derivative 1a, with a sulfur stereogenic center, had the most potent activity as human platelet aggregation inhibitor. The resolution of rac-1a was successfully performed by chiral chromatography on Chiralcel OD-R, OD-H, and Chira