Synthesis of the S-enantiomer of paniculidine A: absolute R-configuration of the natural paniculidines A and B
โ Scribed by Czeskis, Boris A.; Moissenkov, Alexander M.
- Book ID
- 115546645
- Publisher
- Royal Society of Chemistry
- Year
- 1989
- Weight
- 148 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1472-7781
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Topsentolide A 1 Nine-membered lactone Determination of the absolute configuration Marine oxylipin a b s t r a c t Two possible stereoisomers of topsentolide A 1 , a cytotoxic oxylipin against human solid tumor cell lines, were prepared in order to determine the stereochemistry of natural product. T
Both the enantiomers of sclerosporin 1 and sclerosporal 2 were synthesized from (-)carvone. (4R, 9R, lOR)-(+)-Sclerosporin and (4R, 9R, lOR)-(-)-sclerosporal were identified as natural enantiomers by bio-assay and by the CD-spectral comparison. Sclerosporin 1, the main sporogenic substance isolated