The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-l-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary. Absolute configurations have been deduced via X-ray crystallography on a (R)-mandelic
Synthesis and determination of the absolute configuration of the enantiomers of modafinil
β Scribed by Thomas Prisinzano; John Podobinski; Kevin Tidgewell; Min Luo; Dale Swenson
- Book ID
- 108283738
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 296 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Both the enantiomers of sclerosporin 1 and sclerosporal 2 were synthesized from (-)carvone. (4R, 9R, lOR)-(+)-Sclerosporin and (4R, 9R, lOR)-(-)-sclerosporal were identified as natural enantiomers by bio-assay and by the CD-spectral comparison. Sclerosporin 1, the main sporogenic substance isolated
## Abstract The __trans__ isomer of 2,7βdiβ__tert__βbutylnaphtho[1,8β__cd__][1,2]dithiole 1,2βdioxide, a __vic__βdisulfoxide of the highest thermal stability reported to date, has been resolved into its enantiomers by preparative chiral liquid chromatography. This represents the first resolution ac