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Synthesis of the enantiomers of felodipine and determination of their absolute configuration

✍ Scribed by Bo Lamm; Roger Simonsson; Staffan Sundell

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 141 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)93912-7

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✦ Synopsis

The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-l-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary. Absolute configurations have been deduced via X-ray crystallography on a (R)-mandelic acid ester, 9B.

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