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Synthesis of chiral isoquinuclidines and determination of their absolute configuration

✍ Scribed by M. Mehmandoust; C. Marazano; R. Singh; B. Gillet; M. Césario; J.-L. Fourrey; B.C. Das

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
282 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

A route to 1,2_dihydropyridines &-substituted with chiral auxiliaries has been developed starting from commercially available chiral amines. Cycloaddition between these dihydropyridines and methyl acrylate gave, in moderate d.e., isoquinuclidines of good enantiomeric purity whose absolute configuration has been established.

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