Noncompartmental determination of the me
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Haiyung Cheng; William J. Jusko
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Article
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1991
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John Wiley and Sons
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English
โ 233 KB
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Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6