Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion Data
โ Scribed by William R. Gillespie
- Book ID
- 110341975
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 652 KB
- Volume
- 08
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Moment analysis has become widely used in recent years as a noncompartmental approach to the estimation of mean residence time (MRT) and steady-state volume of distribution (Vd,,) from single-dose data.1-5 In 1983, the method was first extended to the multiple-dosing situation by Bauer and Gibaldi.6
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi