Based on disposition decomposition analysis (DDA), equations for the mean residence times (MRT) in the body are derived for a drug and its interconversion metabolite that undergo linear tissue distribution and linear or non-linear elimination from the central compartment after non-instantaneous admi
โฆ LIBER โฆ
Mean residence time of drugs in pharmacokinetic systems with linear distribution, linear or nonlinear elimination, and noninstantaneous input
โ Scribed by Haiyung Cheng; William J. Jusko
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 212 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
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The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug