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Mean residence time of drugs in pharmacokinetic systems with linear distribution, linear or nonlinear elimination, and noninstantaneous input

โœ Scribed by Haiyung Cheng; William J. Jusko


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
212 KB
Volume
80
Category
Article
ISSN
0022-3549

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The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug