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Determination of catechol-O-methyltransferase activity in various tissues by liquid chromatography

✍ Scribed by Shoup, Ronald E.; Davis, Gregory C.; Kissinger, Peter T.

Book ID
127171042
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
638 KB
Volume
52
Category
Article
ISSN
0003-2700

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A sensitive assay for catechol-O-methyltransferase (COMT) activity by high-performance liquid chromatography with on-line radiochemical detection was described. The method was based on the measurement of 3H-labeled 3-O- and 4-O-methylated products of the substrate, 3,4-dihydroxybenzoic acid, using S