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Determination of catechol O-methyltransferase activity in relation to melanin metabolism using high-performance liquid chromatography with fluorimetric detection

✍ Scribed by N.P.M. Smit; S. Pavel; A. Kammeyer; W. Westerhof


Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
506 KB
Volume
190
Category
Article
ISSN
0003-2697

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Determination of catechol-O-methyltransf
✍ Erkki Nissinen πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 English βš– 426 KB

A sensitive assay for catechol-O-methyltransferase (COMT) activity by high-performance liquid chromatography with on-line radiochemical detection was described. The method was based on the measurement of 3H-labeled 3-O- and 4-O-methylated products of the substrate, 3,4-dihydroxybenzoic acid, using S