On the Determination of Catechol-O-Methyltransferase Activity in Tissue Homogenates
โ Scribed by Broch, O. J. ;Guldberg, H. C.
- Book ID
- 114798760
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Weight
- 623 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0001-6683
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๐ SIMILAR VOLUMES
A sensitive assay for catechol-O-methyltransferase (COMT) activity by high-performance liquid chromatography with on-line radiochemical detection was described. The method was based on the measurement of 3H-labeled 3-O- and 4-O-methylated products of the substrate, 3,4-dihydroxybenzoic acid, using S
## Abstract Soman (pinacolyl methylphosphonofluoridate) not only increases acetylcholine levels by inhibiting cholinesterases, it also alters the levels of some other neurotransmitters including norepinephrine, dopamine, and serotonin. Soman also causes an alteration in the activities of the enzyme