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Catechol-O-methyltransferase activity: A determinant of levodopa response

✍ Scribed by Reilly, Douglas K; Rivera-Calimlim, Leonor; Van Dyke, David

Book ID
109842862
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
571 KB
Volume
28
Category
Article
ISSN
0009-9236

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Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol hormones, neurotransmitters and certain drugs. It is subject to genetic polymorphism and ethnic differences. High red blood cell (RBC) COMT activity has been correlated with a poor response to levodopa treatment in Parkinson

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## Abstract The short plasma half‐life limits the antiparkinsonian efficacy of levodopa/carbidopa (LD/CD). Administration of LD/CD with the catechol‐__O__‐methyltransferase inhibitor entacapone in one tablet (LCE) may extend plasma half‐life of LD and thus its effect on motor symptoms in patients w