Correlation of erythrocyte catechol-O-methyltransferase activity between siblings
β Scribed by WEINSHILBOUM, RICHARD M.; RAYMOND, FREDRICK A.; ELVEBACK, LILA R.; WEIDMAN, WILLIAM H.
- Book ID
- 109693655
- Publisher
- Nature Publishing Group
- Year
- 1974
- Tongue
- English
- Weight
- 257 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/252490a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The multistep assay of specific catechol-O-methyltransferase (COMT) activity in human erythrocytes was validated. Enzyme preparations from lysed erythrocytes were incubated with a substrate (3,4-dihydroxybenzoic acid) in the presence of Mg2+ and S-adenosylmethionine. The reaction products (vanillic
The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases