Catechol-O-methyltransferase activity in erythrocytes of children with autism
β Scribed by R. A. O'Brien; G. Semenuk; M. Coleman; S. Spector
- Book ID
- 108932641
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 320 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0305-1870
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π SIMILAR VOLUMES
The multistep assay of specific catechol-O-methyltransferase (COMT) activity in human erythrocytes was validated. Enzyme preparations from lysed erythrocytes were incubated with a substrate (3,4-dihydroxybenzoic acid) in the presence of Mg2+ and S-adenosylmethionine. The reaction products (vanillic
The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases