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Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Calcium Ion-Mobilizing Second Messenger

✍ Scribed by Tsuzuki, Takayoshi; Sakaguchi, Natsumi; Kudoh, Takashi; Takano, Satoshi; Uehara, Masato; Murayama, Takashi; Sakurai, Takashi; Hashii, Minako; Higashida, Haruhiro; Weber, Karin; Guse, Andreas H.; Kameda, Tomoshi; Hirokawa, Takatsugu; Kumaki, Yasuhiro; Potter, Barry V. L.; Fukuda, Hayato; Arisawa, Mitsuhiro; Shuto, Satoshi


Book ID
120498870
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
1009 KB
Volume
52
Category
Article
ISSN
0044-8249

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Design and synthesis of 4β€³,6β€³-unsaturate
✍ Takashi Kudoh; Karin Weber; Andreas H. Guse; Barry V.L. Potter; Minako Hashii; H πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 185 KB

4 00 ,6 00 -Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca 2+ -mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-pheny