𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic ribose as a Ca2+-mobilizing agent

✍ Scribed by Takashi Kudoh; Karin Weber; Andreas H. Guse; Barry V.L. Potter; Minako Hashii; Haruhiro Higashida; Mitsuhiro Arisawa; Akira Matsuda; Satoshi Shuto

Book ID
104095356
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
185 KB
Volume
49
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

4 00 ,6 00 -Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca 2+ -mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-phenyl phosphorothioate-type substrate. Biological evaluation showed that 4 00 ,6 00 -didehydro-cADPcR is a potent Ca 2+ -mobilizing agent in T cells.

📜 SIMILAR VOLUMES

ChemInform Abstract: Intracellular Ca2+-
ChemInform Abstract: Intracellular Ca2+-Mobilizing Adenine Nucleotides. Synthesis and Biological Activity of Cyclic ADP-Carbocyclic-Ribose and C-Glycosidic Analogue of Adenophostin A
✍ Satoshi Shuto; Masayoshi Fukuoka; Hiroshi Abe; Akira Matsuda 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v