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Total Synthesis of Cyclic ADP-carbocyclic-ribose, a Stable Mimic of Ca 2+ -Mobilizing Second Messenger Cyclic ADP-Ribose 1

✍ Scribed by Shuto, Satoshi; Fukuoka, Masayoshi; Manikowsky, Andrzej; Ueno, Yoshihito; Nakano, Takashi; Kuroda, Ritsu; Kuroda, Hideyo; Matsuda, Akira


Book ID
127256963
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
151 KB
Volume
123
Category
Article
ISSN
0002-7863

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4 00 ,6 00 -Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca 2+ -mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-pheny