Convergent Synthesis and Unexpected Ca 2+ -Mobilizing Activity of 8-Substituted Analogues of Cyclic ADP-Carbocyclic-Ribose, a Stable Mimic of the Ca 2+ -Mobilizing Second Messenger Cyclic ADP-Ribose
β Scribed by Shuto, Satoshi; Fukuoka, Masayoshi; Kudoh, Takashi; Garnham, Clive; Galione, Antony; Potter, Barry V. L.; Matsuda, Akira
- Book ID
- 126197429
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 194 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
4 00 ,6 00 -Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca 2+ -mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-pheny
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