Design and Synthesis of C 3 -Symmetric Lewis X Antigen
β Scribed by Nishida, Yoshihiro; Tsurumi, Tomoaki; Sasaki, Kenji; Watanabe, Kenta; Dohi, Hirofumi; Kobayashi, Kazukiyo
- Book ID
- 127043168
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 123 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
In connection with studies on the solution and protein-bound conformation of oligosaecharides, we had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3)
Readily available fucosyl ct(l-3)azidoglucose disaccharide 6 is transformed with galactosyl donors 7 and 8 into Lewis X trisacchadde building blocks 9 and 12, respectively, in high yield. Their suitability for the construction of the lactoneo-series glycosphingolipids is demonstrated. For instance,