Design and Synthesis of Sialyl Lewis X Mimetics
β Scribed by Uchiyama, Taketo; Vassilev, Vassil P.; Kajimoto, Tetsuya; Wong, Weichyun; Lin, Chun-Cheng; Huang, Hongmei; Wong, Chi-Huey
- Book ID
- 120529443
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 240 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Two rigid macrocyclic glycopeptides 1 and 2 were designed to mimic the tetrasaccharide SLe X as inhibitors of P-selectin. While compound 1 was found to be 1000-fold more potent than SLe X with IC 50 =1 mM, compound 2 was not soluble in water for evaluation of its activity.
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