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Design and synthesis of cyclic sialyl Lewis X mimetics: a remarkable enhancement of inhibition by pre-organizing all essential functional groups

✍ Scribed by Chung-Ying Tsai; Xuefei Huang; Chi-Huey Wong

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 89 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01653-1

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✦ Synopsis

Two rigid macrocyclic glycopeptides 1 and 2 were designed to mimic the tetrasaccharide SLe X as inhibitors of P-selectin. While compound 1 was found to be 1000-fold more potent than SLe X with IC 50 =1 mM, compound 2 was not soluble in water for evaluation of its activity.

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ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Cyclic Sialyl Lewis X Mimetics: A Remarkable Enhancement of Inhibition by Pre-Organizing All Essential Functional Groups.

✍ Chung-Ying Tsai; Yuefei Huang; Chi-Huey Wong 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

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