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Efficient synthesis of lactoneo series antigens H, Lewis X (Lex), and Lewis Y (Ley)1

✍ Scribed by Rainer Windmüller; Richard R. Schmidt

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
253 KB
Volume
35
Category
Article
ISSN
0040-4039

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A versatile synthesis of the lactoneo-se
A versatile synthesis of the lactoneo-series antigens — synthesis of sialyl dimer Lewis X and of dimer Lewis Y
✍ Gerd Hummel; Richard R Schmidt 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 254 KB

Readily available fucosyl ct(l-3)azidoglucose disaccharide 6 is transformed with galactosyl donors 7 and 8 into Lewis X trisacchadde building blocks 9 and 12, respectively, in high yield. Their suitability for the construction of the lactoneo-series glycosphingolipids is demonstrated. For instance,